Simon Frost's research interests focus on the use of mathematical and statistical modelling to understanding the dynamics and evolution of infectious diseases, predominantly RNA viruses such as HIV, hepatitis C and influenza A. Simon’s current projects include the statistical modelling of evolutionary processes acting on genetic sequences, modelling viral and immune dynamics, designing diagnostics for viral infections, mining of large clinical databases, and investigating novel means of capturing social, sexual and disease transmission networks, particularly in the context of emerging infectious disease. He is also involved in modelling retroviral transmission in western Uganda and the transmission dynamics of leptospirosis in the Peruvian Amazon.